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Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboličkog puta. U studiji kod zdravih dobrovoljaca primena two hundred mg itrakonazola dnevno tokom 4 dana povećala je PIK pojedinačne oralne doze od 5 mg diazepama za oko fifteen%, ali ova interakcija nije bila od kliničkog značaja, što je potvrđeno psihomotornim testo

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Fenitoin je poznati induktor CYP3A4 izoenzima i ubrzava metabolizam diazepama u jetri. Smanjeno dejstvo diazepama. Diazepam deluje na metabolizam fenitoina na nepredvidiv način: metabolizam fenitoina pod dejstvom diazepama može biti ubrzan ili usporen, ili ostati nepromenjen.IMPORTANT: Because of the danger of misuse, overdose or other dangerous

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Inform people that in some instances, people getting benzodiazepines have developed a protracted withdrawal syndrome with withdrawal indications lasting months to a lot more than twelve months. Instruct individuals that discontinuation or dosage reduction of diazepam tablets may possibly demand a gradual taper (see WARNINGS: Dependence and Withdraw

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Opioids must only be utilized by People they are prescribed for. Never give your medication to everyone else. Having greater doses or maybe more Regular doses of opioid, could increase the threat of dependancy. Overuse and misuse may lead to overdose and/or Dying.Urgent advice: Simply call 999 in the event you've taken an excessive amount co-codamo

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